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Can we use nasal swab to guide empiric antibiotic therapy in ventilator-associated pneumonia? See the results from the retrospective analysis of more than 1400 patients in our ICU. Free full text here on Antibiotics Abstract The guidelines on ventilator-associated pneumonia (VAP) recommend an empiric therapy against methicillin-resistant Staphylococcus aureus (MRSA) according to its prevalence rate. […]

Enrolments are open! See rationale and details of the IPERPEEP protocol Free full text here on Trial   Background In acute respiratory distress syndrome (ARDS), response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability. The search for a tool to individualize PEEP based on patients’ individual response is warranted. […]

Central line-associated bloodstream infection prevention bundles   Are we doing enough?   Look at the results of this international survey on American Journal of Infection Control Abstract Background: Because central line-associated bloodstream infections (CLABSIs) are a significant complication of central venous access, it is critical to prevent CLABSIs through the use of central line bundles. […]

COVID-19 vaccine significantly reduced the risk of ICU admission for COVID-19 pneumonia, even when adjusted by confounders as age and sex. No difference in ICU outcome was observed between vaccinated and unvaccinated patients, even if vaccinated ones had more risk factors since they were older and with more comorbidities. Have a look the the results of […]

Good clinical outcome of kidney from DCD despite the long “no touch period”! See the report on 11-year Italian experience; Free full text here on Transplant International   Abstract Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal […]

Can we improve patient-ventilator interaction with waveform analysis? Have a look to this prospective randomised crossover study on Anaesthesia Critical Care & Pain Medicine.   Abstract Objective To test the performance of a software able to control mechanical ventilator cycling-off by means of automatic, real-time analysis of ventilator waveforms during pressure support ventilation. Design Prospective […]